Developmental CNS Model - Mammal

The Developmental Model is a closed hierarchical Model of the mammalian central nervous system (CNS), the core Encephalon/brain of which is based largely on studies of genetic control of neural development in the mouse. The findings are sufficiently consistent with information about highly conserved genes found in all mammalian species that the Model is considereds applicable to all mammals ( Puelles-2013, Watson-2017 ). The authors provide both Latin and English names for structures in the Model. In the NeuroNames Standard Nomenclature, the hierarchy for embryonic structures is modeled separately from the hierarchical Model for adult central nervous system (CNS) structures in different species, such as, Structural CNS Model - Macaque. In the Developmental Model, all structure names are capitalized and in Latin. in Model of the mature nervous system, standard structure names are in English. The top three or four levels of the Developmental Model are drawn from Puelles-2013 and Watson-2017. Further differentiation of branches from those levels and for the spinal cord (SPC) are Latin name ffor structures referenced English in the Structural CNS - Human.Neuronal populations have been classified on the basis of progressive rostrocaudal and dorsoventral differentiation of the neural tube. Radially migrated derivatives can be traced from progenitor areas based on fate mapping, gene mapping, and other experimental evidence. The overall purpose is to describe and illustratea consistent spatial organisztion between the embryonic CNS and the adult CNS. The result is a complete ontology of the CNS in mammals, i.e., a hierarchical list of names and operational definitions of the structures they represent ( Gruberr-1993, Bowden-2012 ).