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Wallis JD (2011). Cross-species studies of orbitofrontal cortex and value-based decision-making. Nat Neurosci. 15:1:13-9. doi: 10.1038/nn.2956. PMID: 22101646; PMCID: PMC3549638.
ABSTRACT
Recent work has emphasized the role that orbitofrontal cortex (OFC) plays in value-based decision-making. However, it is also clear that a number of discrepancies have arisen when comparing the findings from animal models to those from humans. In this paper, we examine several possibilities that might explain these discrepancies including anatomical difference between species, the behavioral tasks used to probe decision-making and the methodologies used to assess neural function. Understanding how these differences affect the interpretation of experimental results will help us better integrate future results from animal models. This will enable us to fully realize the benefits of using multiple approaches to understand OFC function.
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